Despite the questionable usefulness of opioids in handling CNCP as well as their high prices of Negative effects, the absence of available substitute medications and their medical restrictions and slower onset of action has resulted in an overreliance on opioids. Conolidine is surely an indole alkaloid derived with the bark with the tropical flower

Although the opiate receptor relies on G protein coupling for signal transduction, this receptor was identified to benefit from arrestin activation for internalization in the receptor. Normally, the receptor promoted no other signaling cascades (59) Modifications of conolidine have resulted in variable improvement in binding efficacy. This binding